9SYP

Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with dual chaperon targeting ligand THOR-1

This is a non-PDB format compatible entry.

Summary for 9SYP

• Entry DOI: 10.2210/pdb9syp/pdb
• Descriptor: Heat shock cognate 71 kDa protein, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ~{N}-[3,5-bis(oxidanyl)phenyl]-2-(1~{H}-indol-2-ylsulfanyl)ethanamide, ... (7 entities in total)
• Functional Keywords: protein ligand complex of dual chaperone ligand at hsc70 substrate binding domain, chaperone
• Biological source: Bos taurus (domestic cattle)
• Total number of polymer chains: 1
• Total formula weight: 61790.27

Authors

Zehe, M.,Brenner, M.,Sotriffer, C. (deposition date: 2025-10-13, release date: 2026-10-28)

• Primary citation: Zehe, M.,Brenner, M.,Bothe, S.,Marzouk, M.,Gehrig, T.,Schindelin, H.,Sotriffer, C.; Unlocking Dual Targeting: Fragment-Growing towards simultaneous Inhibition of Hsc70 and Hsp90; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.97 Å)