9SYO

Crystal structure of human Hsp90-alpha NBD(aa9-236)in complex with dual chaperon targeting ligand THOR-1

This is a non-PDB format compatible entry.

Summary for 9SYO

• Entry DOI: 10.2210/pdb9syo/pdb
• Related: 9SYP
• Descriptor: Heat shock protein HSP 90-alpha, ~{N}-[3,5-bis(oxidanyl)phenyl]-2-(1~{H}-indol-2-ylsulfanyl)ethanamide, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: protein ligand complex of dual chaperone ligand at hsp90 nucleotide binding site, chaperone
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 51652.20

Authors

Brenner, M.,Zehe, M.,Schindelin, H.,Sotriffer, C. (deposition date: 2025-10-13, release date: 2026-10-28)

• Primary citation: Zehe, M.,Brenner, M.,Bothe, S.,Marzouk, M.,Gehrig, T.,Schindelin, H.,Sotriffer, C.; Unlocking Dual Targeting: Fragment-Growing towards simultaneous Inhibition of Hsc70 and Hsp90; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.29 Å)