9SXG

PDGFRA T674I mutant kinase domain in complex with AZD7762

Summary for 9SXG

• Entry DOI: 10.2210/pdb9sxg/pdb
• Descriptor: Platelet-derived growth factor receptor alpha, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: pdgfra protein kinase, azd7762, inhibitor, tyrosine kinase, transmembrane receptor, platelet-derived growth factor receptor alpha, pdgf, platelet-derived growth factor, gist, gastrointestinal stromal tumors, gatekeeper mutant, p16234, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40906.14

Authors

Teuber, A.,Kleinboelting, S.B.,Mueller, M.P.,Rauh, D. (deposition date: 2025-10-09, release date: 2026-10-21)

• Primary citation: Muehlenberg, T.,Teuber, A.,Kleinboelting, S.B.,Mueller, M.P.,Rauh, D.; Compound-screen identifies first-in-class inhibitor of multi-drug resistant KIT and PDGFRA AP/AL mutations; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.27 Å)