9SXF

c-KIT kinase domain in complex with (R)-Pyrrolidine derivative of AZD7762

Summary for 9SXF

Entry DOI	10.2210/pdb9sxf/pdb
Descriptor	Mast/stem cell growth factor receptor Kit, 3-(aminocarbonylamino)-5-(3-fluorophenyl)-~{N}-[(3~{R})-pyrrolidin-3-yl]thiophene-2-carboxamide (3 entities in total)
Functional Keywords	c-kit, protein kinase, azd7762, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, stem cell factor receptor, gist, gastrointestinal stromal tumors, p10721, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	37542.82
Authors	Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2025-10-09, release date: 2026-10-21)
Primary citation	Muehlenberg, T.,Teuber, A.,Kleinboelting, S.B.,Mueller, M.P.,Rauh, D. Compound-screen identifies first-in-class inhibitor of multi-drug resistant KIT and PDGFRA AP/AL mutations To Be Published,
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation