9SVI

Cryo-EM structure of CRBN bound to 1-[1-(4-piperidyl)indol-4-yl]hexahydropyrimidine-2,4-dione in the open conformation

This is a non-PDB format compatible entry.

Summary for 9SVI

• Entry DOI: 10.2210/pdb9svi/pdb
• EMDB information: 55259
• Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION, ... (4 entities in total)
• Functional Keywords: e3 ubiquitin ligase, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 144284.41

Authors

Cowan, A.D.,Rutter, Z.J.,McAulay, K.,Ciulli, A. (deposition date: 2025-10-03, release date: 2026-10-14)

• Primary citation: Rutter, Z.J.,Cowan, A.D.,McAulay, K.,Ciulli, A.; Structural and Biophysical Methods for the Assessment of Cereblon Binders for PROTACs; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.33 Å)