9SUN

Crystal structure of CRBN-midi in complex with 1-(1-(piperidin-4-yl)-1H-indol-4-yl)dihydropyrimidine-2,4(1H,3H)-dione

This is a non-PDB format compatible entry.

Summary for 9SUN

• Entry DOI: 10.2210/pdb9sun/pdb
• Descriptor: Protein cereblon, 1-(1-piperidin-4-ylindol-4-yl)-1,3-diazinane-2,4-dione, ZINC ION, ... (4 entities in total)
• Functional Keywords: e3 ligase, protac, molecular glue, targeted protein degradation, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 75713.16

Authors

Rutter, Z.J.,McAulay, K.,Ciulli, A. (deposition date: 2025-09-29, release date: 2026-10-07)

• Primary citation: Rutter, Z.J.,McAulay, K.,Ciulli, A.; Structural and Biophysical Methods for the Assessment of Cereblon Binders for PROTACs; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.36 Å)