9SRI

Human DNA polymerase epsilon bound to DNA blunt end

Summary for 9SRI

• Entry DOI: 10.2210/pdb9sri/pdb
• EMDB information: 55141
• Descriptor: DNA polymerase epsilon catalytic subunit A, Proliferating cell nuclear antigen, Primer DNA oligonucleotide, ... (5 entities in total)
• Functional Keywords: pole1, dna, polymerase, epsilon, pcna, leading strand, replication, replisome, dna binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 244000.77

Authors

Roske, J.J.,Yeeles, J.T.P. (deposition date: 2025-09-24, release date: 2026-03-18)

• Primary citation: Roske, J.J.,Yeeles, J.T.P.; Cryo-EM maps of human DNA polymerase epsilon should be reevaluated in light of its unexpected behavior in vitro.; Proc.Natl.Acad.Sci.USA, 123:e2533320123-e2533320123, 2026; PubMed: 41790928; DOI: 10.1073/pnas.2533320123

Experimental method

ELECTRON MICROSCOPY (3.3 Å)