9SQW

Cryo-EM structure of the ARISCdC(E33A):K63-Ub7 complex (Composite map)

Summary for 9SQW

Entry DOI	10.2210/pdb9sqw/pdb
EMDB information	55119
Descriptor	BRCA1-A complex subunit Abraxas 1, Ubiquitin, Lys-63-specific deubiquitinase BRCC36, ... (5 entities in total)
Functional Keywords	deubiquitylating enzymes, jamm/mpn family, ubiquitin chains, dna damage repair, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	10
Total formula weight	262032.01
Authors	Foglizzo, M.,Degtjarik, O.,Zeqiraj, E. (deposition date: 2025-09-23, release date: 2026-08-05)
Primary citation	Foglizzo, M.,Datta, A.,Degtjarik, O.,Perera, H.,Liburd, J.,Sykora, U.M.,Ganji, R.S.,Wildsmith, G.,Chandler, F.,Campbell, L.J.,Calabrese, A.N.,Greenberg, R.A.,Zeqiraj, E. Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex To Be Published,
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation