9SPV

focused structure of regulatory domains of cis-basal conformer of human CBS induced by non-activating allosteric SAO ligand - by Helical approach

Summary for 9SPV

• Entry DOI: 10.2210/pdb9spv/pdb
• EMDB information: 55097
• Descriptor: Cystathionine beta-synthase, SINEFUNGIN (2 entities in total)
• Functional Keywords: transsulfuration pathway, l-serine hydro-lyase, heme-binding protein, cbs domain, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 609704.85

Authors

Inayathulla, M.,Tomas, M. (deposition date: 2025-09-18, release date: 2026-07-29)

• Primary citation: Mohammed, I.,Mijatovic, E.,Philipp, T.M.,Janickova, L.,Ascencao, K.,Asturias, F.J.,Martinez-Cruz, L.A.,Szabo, C.,Stahlberg, H.,Majtan, T.; Structural basis for a filamentous morpheein model of human cystathionine beta-synthase; Nat Commun, 2026; DOI: 10.1038/s41467-026-73198-7

Experimental method

ELECTRON MICROSCOPY (4.04 Å)