9SHN

Structure of trans-basal conformer of human CBS trapped in PLP-serine external aldemine intermediate (CBS-PLP-Ser)- by single particle approach

Summary for 9SHN

• Entry DOI: 10.2210/pdb9shn/pdb
• EMDB information: 54905
• Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine (3 entities in total)
• Functional Keywords: transsulfuration pathway, l-serine hydro-lyase, heme-binding protein, cbs domain, cytosolic protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 114706.78

Authors

Inayathulla, M.,Tomas, M. (deposition date: 2025-08-27, release date: 2026-07-29)

• Primary citation: Mohammed, I.,Mijatovic, E.,Philipp, T.M.,Janickova, L.,Ascencao, K.,Asturias, F.J.,Martinez-Cruz, L.A.,Szabo, C.,Stahlberg, H.,Majtan, T.; Structural basis for a filamentous morpheein model of human cystathionine beta-synthase; Nat Commun, 2026; DOI: 10.1038/s41467-026-73198-7

Experimental method

ELECTRON MICROSCOPY (2.18 Å)