9S6T

Ternary cryo-EM structure of chicken ALG12 with Dol25-PP-GlcNAc2Man7, Dol25-P-Man, and Fab

This is a non-PDB format compatible entry.

Summary for 9S6T

• Entry DOI: 10.2210/pdb9s6t/pdb
• EMDB information: 54631
• Descriptor: Mannosyltransferase, Gg12-11 Fab heavy chain, Gg12-11 Fab light chain, ... (8 entities in total)
• Functional Keywords: mannosyltransferase, ternary complex, n-linked glycosylation, transferase
• Biological source: Gallus gallus (chicken); More
• Total number of polymer chains: 3
• Total formula weight: 108756.44

Authors

Alexander, J.A.N.,Chen, S.Y.,Mukherjee, S.,de Capitani, M.,Irobalieva, R.N.,Rossi, L.,Agrawal, P.,Kowal, J.,Meirelles, M.A.,Aebi, M.,Reymond, J.L.,Kossiakoff, A.A.,Riniker, S.,Locher, K.P. (deposition date: 2025-08-01, release date: 2026-03-18)

• Primary citation: Alexander, J.A.N.,Chen, S.Y.,Mukherjee, S.,de Capitani, M.,Irobalieva, R.N.,Rossi, L.,Agrawal, P.,Kowal, J.,Meirelles, M.A.,Aebi, M.,Reymond, J.L.,Kossiakoff, A.A.,Riniker, S.,Locher, K.P.; Structural basis for oligomannose N-glycan synthesis in the endoplasmic reticulum; Nat.Chem.Biol., 2026; DOI: 10.1038/s41589-026-02164-7

Experimental method

ELECTRON MICROSCOPY (2.42 Å)