9RX6

VPS34-CII (VPS34 199-REIE-202 to 199-ERIR-202 mutant) bound to RAB5A (Q79L) on the VPS15 subunit

Summary for 9RX6

• Entry DOI: 10.2210/pdb9rx6/pdb
• EMDB information: 54322 54359
• Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3, GUANOSINE-5'-TRIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 4, ... (10 entities in total)
• Functional Keywords: lipid kinase, gtpase, kinase, endocytic sorting, endosome maturation, signaling protein, endocytosis
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 411252.54

Authors

Spokaite, S.,Ohashi, Y.,Dessus, A.N.,Bourguet, M.,Williams, R.L. (deposition date: 2025-07-10, release date: 2026-06-03)

• Primary citation: Spokaite, S.,Ohashi, Y.,Bourguet, M.,Dessus, A.N.,Williams, R.L.; A novel RAB5 binding site in human VPS34-CII that is likely the primordial site in eukaryotic evolution; Elife, 2026; DOI: 10.7554/eLife.110040.3

Experimental method

ELECTRON MICROSCOPY (3.52 Å)