9RTS

Crystal structure of BRAF:MEK1(pS222) complex with asymmetric dimer interface bound to ADP

Summary for 9RTS

• Entry DOI: 10.2210/pdb9rts/pdb
• Related: 9RTQ
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, Serine/threonine-protein kinase B-raf, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: kinase, complex, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 139990.47

Authors

Kondo, Y.,Notbohm, J.,Camacho, I.N.,Nagy-Davidescu, G.,Mason, T.,Muhle, J.,Standfuss, J.,Perica, T. (deposition date: 2025-07-03, release date: 2026-07-15)

• Primary citation: Kondo, Y.,Notbohm, J.,Camacho, I.N.,Nagy-Daivescu, G.,Mason, T.,Muhle, J.,Standfuss, J.,Perica, T.; Structural insights into phosphorylation of the MEK1 activation loop by a BRAF asymmetric dimer; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)