9RTG

Crystal structure of Ara h 2 immunocomplex with IgE Fab fragment

Summary for 9RTG

• Entry DOI: 10.2210/pdb9rtg/pdb
• Descriptor: D08 IgE Fab fragment, L-chain, D08 IgE Fab fragment, H-chain, Conglutin-7 (3 entities in total)
• Functional Keywords: ige fab fragment, peanut allergen, immunocomplex, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 14
• Total formula weight: 330717.58

Authors

Parkkinen, T.,Rouvinen, J. (deposition date: 2025-07-02, release date: 2026-06-24)

Primary citation

Parkkinen, T.,Heiniluoto, H.,Janis, J.,Takkinen, K.,Rouvinen, J.
Structural Basis for Trivalent Cross-Linking of a Patient-Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201.
Allergy, 81:2036-2046, 2026

PubMed Abstract: Peanut allergy is a serious form of food allergy that can lead to anaphylactic reactions. Research has shown that the Ara h 2 allergen is immunodominant and associated with fatal systemic reactions.

PubMed: 41700105
DOI: 10.1111/all.70258

Experimental method

X-RAY DIFFRACTION (3.19 Å)