9RSC

Ternary complex of an improved charged molecular glue degrader ZZ2-SO2H, BRD4(BD1) neosubstrate, and the CTLH E3 ligase receptor module YPEL5-WDR26

This is a non-PDB format compatible entry.

Summary for 9RSC

• Entry DOI: 10.2210/pdb9rsc/pdb
• EMDB information: 54194 54215
• Descriptor: WD repeat-containing protein 26, Protein yippee-like 5, Bromodomain-containing protein 4, ... (6 entities in total)
• Functional Keywords: e3 ubiquitin ligase, ctlh, gid, ypel5, molecular glue degrader, targeted protein degradation, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 171037.46

Authors

Chrustowicz, J.,Schulman, B.A. (deposition date: 2025-07-01, release date: 2026-04-08)

• Primary citation: Zhuang, Z.,Woong Sub, B.,Chrustowicz, J.,Kozicka, Z.,Hinshaw, S.M.,Li, V.L.,Donovan, K.A.,Sepic, S.,You, I.,Slabicki, M.,Fischer, E.S.,Ebert, B.L.,Schulman, B.A.,Gray, N.S.; Molecular Glue Prodrug Discovery Enabled by Targeted Degron Display; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.42 Å)