9RRY

Crystal structure of the human METTL3-METTL14 in complex with compound 1 (AD-79)

This is a non-PDB format compatible entry.

Summary for 9RRY

• Entry DOI: 10.2210/pdb9rry/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N(6)-adenosine-methyltransferase non-catalytic subunit METTL14, 8-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-2-[6-(methylamino)pyrimidin-4-yl]-2,5,8-triazaspiro[3.5]nonan-6-one, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, m6a, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 62666.50

Authors

Bedi, R.K.,Dolbois, A.,Caflisch, A. (deposition date: 2025-06-30, release date: 2026-03-18)

• Primary citation: Corbeski, I.,Bedi, R.K.,Matter, C.M.,Stamm, F.,Bochenkova, E.,Herok, M.,Hartshorn, M.J.,Caflisch, A.; Ligand-Induced Opening of a Cryptic Pocket in METTL14; Acs Bio Med Chem Au, 2026; DOI: 10.1021/acsbiomedchemau.5c00184

Experimental method

X-RAY DIFFRACTION (1.91 Å)