9RNJ

Cryo-EM structure of the human potassium chloride cotransporter T906A/T1007A phospho-knockout mutants KCC2b bound ATP in LMNG (outward-facing state, dimer)

Summary for 9RNJ

• Entry DOI: 10.2210/pdb9rnj/pdb
• EMDB information: 54094
• Descriptor: Isoform 2 of Solute carrier family 12 member 5, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: membrane protein, transporter, cation/chloride cotransporter
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 260061.78

Authors

Matsuoka, R.,Oswald, C.,Jazayeri, A.,Duerr, K.L. (deposition date: 2025-06-19, release date: 2026-07-08)

• Primary citation: Matsuoka, R.,Oswald, C.,Jazayeri, A.,Duerr, K.L.; Distinct cytoplasmic domain interactions control autoinhibition of the neuronal potassium coupled chloride transporter KCC2; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.86 Å)