9RM7

Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0036543

This is a non-PDB format compatible entry.

Summary for 9RM7

• Entry DOI: 10.2210/pdb9rm7/pdb
• Descriptor: Serine protease subunit NS2B,Serine protease NS3, DIMETHYL SULFOXIDE, (2~{S})-~{N}-[2,2-bis(fluoranyl)ethyl]-2-(2,3-dihydro-1~{H}-isoindol-5-ylamino)-2-[3-methyl-5-(trifluoromethyl)phenyl]ethanamide, ... (4 entities in total)
• Functional Keywords: ns2b-ns3 protease, inhibitor, viral protein
• Biological source: Zika virus; More
• Total number of polymer chains: 2
• Total formula weight: 46825.77

Authors

Ni, X.,Marples, P.G.,Godoy, A.S.,Koekemoer, L.,Aschenbrenner, J.C.,Balcomb, B.H.,Fairhead, M.,Lithgo, R.M.,Lee, A.,Kenton, N.,Thompson, W.,Tomlinson, C.W.E.,Wild, C.,Winokan, M.,Williams, E.P.,Fearon, D.,von Delft, F. (deposition date: 2025-06-17, release date: 2025-07-23)

• Primary citation: Ni, X.,Marples, P.G.,Godoy, A.S.,Koekemoer, L.,Aschenbrenner, J.C.,Balcomb, B.H.,Fairhead, M.,Lithgo, R.M.,Lee, A.,Kenton, N.,Thompson, W.,Tomlinson, C.W.E.,Wild, C.,Winokan, M.,Williams, E.P.,Fearon, D.,von Delft, F.; Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0036543; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.45 Å)