9RM2

BKPyV VP1 IN COMPLEX WITH 319C07-FAB

9RM2 の概要

• エントリーDOI: 10.2210/pdb9rm2/pdb
• 分子名称: 319C07 antibody heavy chain, Fab fragment, PENTAETHYLENE GLYCOL, HEXAETHYLENE GLYCOL, ... (12 entities in total)
• 機能のキーワード: fab antibody bkpyv vp1 virus capsid, viral protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 408452.61

構造登録者

Schmitt, S.,Hillenbrand, M. (登録日: 2025-06-17, 公開日: 2025-07-09, 最終更新日: 2025-07-30)

主引用文献

Weber, M.,Schmitt, S.,Eicher, B.,Seidenberg, J.,Rutkauskaite, J.,Stockli, B.,Townsend, C.,Huynh-Do, U.,Schachtner, T.,Delbue, S.,Mader, A.,Esslinger, C.,Hillenbrand, M.
A highly potent human antibody neutralizing all serotypes of BK polyomavirus.
Plos Pathog., 21:e1013122-e1013122, 2025

PubMed Abstract: BK polyomavirus infection poses a significant risk to kidney transplant recipients. Reactivation of dormant virus in the transplanted kidney, triggered by immunosuppression, can lead to BK polyomavirus-associated nephropathy in up to 10% of transplants, often resulting in loss of graft function or even graft loss. Currently, there is no specific treatment that reliably prevents BK polyomavirus-associated nephropathy or halts its progression. Standard of care relies on reducing immunosuppression, allowing the immune system to gradually control the infection but at the risk of provoking rejection episodes and compromising kidney function. This study describes the discovery and characterization of a highly-potent BK polyomavirus-neutralizing antibody, identified from a kidney transplant recipient who displayed rapid clearance of high-level BKPyV-DNAemia. Antibody mAb 319C07 (USAN potravitug) neutralizes all four BK polyomavirus serotypes and recognizes an epitope critical for viral cell attachment. mAb 319C07 is in clinical development for the treatment of BKPyV infection in renal transplant patients (NCT05769582).

PubMed: 40680077
DOI: 10.1371/journal.ppat.1013122

実験手法

X-RAY DIFFRACTION (1.96 Å)