9RL5

a5b3 GABAAR bound to Topiramate, GABA, and Mb25 in a desensitized state in saposin nanodiscs

Summary for 9RL5

• Entry DOI: 10.2210/pdb9rl5/pdb
• EMDB information: 54031
• Descriptor: Green fluorescent protein,Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, GAMMA-AMINO-BUTANOIC ACID, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate, ... (13 entities in total)
• Functional Keywords: gabaa receptor, pentameric ligand gated ion channel, ion channel, anticonvulsant, membrane protein
• Biological source: Aequorea victoria; More
• Total number of polymer chains: 6
• Total formula weight: 431668.31

Authors

Cowgirl, J.,Lindahl, E.,Howard, R.J. (deposition date: 2025-06-16, release date: 2026-03-18)

• Primary citation: Cowgill, J.,Howard, R.J.,Lindahl, E.; Structural basis for activation and potentiation in a human a5b3 GABAA receptor; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)