9RGC

Recombinant Human Butyrylcholinesterase in complex with LP1488 (7-[(4-{[(3,4-dimethoxybenzyl)(methyl)amino]methyl}benzyl)oxy]-4-(hydroxymethyl)-2H-chromen-2-one)

This is a non-PDB format compatible entry.

Summary for 9RGC

• Entry DOI: 10.2210/pdb9rgc/pdb
• Descriptor: Cholinesterase, SODIUM ION, CHLORIDE ION, ... (12 entities in total)
• Functional Keywords: butyrylcholinesterase, inhibitor, complex, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 64130.01

Authors

Brazzolotto, X.,Pisani, L. (deposition date: 2025-06-06, release date: 2026-05-27)

• Primary citation: Rullo, M.,La Spada, G.,Brazzolotto, X.,Marchese, S.,El Idrissi, I.G.,Miciaccia, M.,Colella, M.,Brea, J.M.,Macchia, E.,Loza, M.I.,Gottinger, A.,Scilimati, A.,Perrone, M.G.,Stefanachi, A.,Binda, C.,Leonetti, F.,Pisani, L.; Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes; Eur.J.Med.Chem., :118961-, 2026; DOI: 10.1016/j.ejmech.2026.118961

Experimental method

X-RAY DIFFRACTION (2.36 Å)