9RF5

M. tuberculosis meets European Lead Factory: identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography: ELF8

Summary for 9RF5

Entry DOI	10.2210/pdb9rf5/pdb
Descriptor	Monoacylglycerol lipase, [(3~{R})-3-oxidanylpyrrolidin-1-yl]-[4-[2-[3-(trifluoromethyloxy)phenyl]-1,3-oxazol-5-yl]phenyl]methanone, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (7 entities in total)
Functional Keywords	rv0183, inhibitor, monoacylglycerol lipase, hydrolase
Biological source	Mycobacterium tuberculosis H37Rv
Total number of polymer chains	1
Total formula weight	34472.95
Authors	Riegler-Berket, L.,Goedl, L.,Oberer, M.,Polidori, N. (deposition date: 2025-06-04, release date: 2025-08-13, Last modification date: 2025-10-29)
Primary citation	Riegler-Berket, L.,Godl, L.,Polidori, N.,Aschauer, P.,Grininger, C.,Prosser, G.,Lichtenegger, J.,Sagmeister, T.,Parigger, L.,Gruber, C.C.,Reiling, N.,Oberer, M. M. tuberculosis meets European lead factory:Identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography Disease and Therapeutics, 1:100002-, 2025 Cited by DOI: 10.1016/j.dist.2025.100002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation