9RF2

M. tuberculosis meets European Lead Factory: identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography: ELF5

9RF2 の概要

• エントリーDOI: 10.2210/pdb9rf2/pdb
• 分子名称: Monoacylglycerol lipase, [1-[6-[(4-methoxyphenyl)amino]pyrimidin-4-yl]pyrazol-4-yl]-[(3S)-3-oxidanylpyrrolidin-1-yl]methanone, [1-[6-[(4-methoxyphenyl)amino]pyrimidin-4-yl]pyrazol-4-yl]-[(3R)-3-oxidanylpyrrolidin-1-yl]methanone, ... (5 entities in total)
• 機能のキーワード: rv0183, inhibitor, monoacylglycerol lipase, hydrolase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34414.30

構造登録者

Riegler-Berket, L.,Goedl, L.,Oberer, M.,Polidori, N. (登録日: 2025-06-04, 公開日: 2025-08-13, 最終更新日: 2025-10-29)

• 主引用文献: Riegler-Berket, L.,Godl, L.,Polidori, N.,Aschauer, P.,Grininger, C.,Prosser, G.,Lichtenegger, J.,Sagmeister, T.,Parigger, L.,Gruber, C.C.,Reiling, N.,Oberer, M.; M. tuberculosis meets European lead factory:Identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography; Disease and Therapeutics, 1:100002-, 2025; DOI: 10.1016/j.dist.2025.100002

実験手法

X-RAY DIFFRACTION (1.6 Å)