9RBL

Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide MKV558

This is a non-PDB format compatible entry.

Summary for 9RBL

• Entry DOI: 10.2210/pdb9rbl/pdb
• Descriptor: Carbonic anhydrase 9, ZINC ION, 3-(Cyclooctylamino)-5-ethoxy-2,6-difluoro-4-((3-hydroxypropyl)sulfonyl)benzenesulfonamide, ... (4 entities in total)
• Functional Keywords: ca ix, ca 9, carbonic anhydrase ix, carbonic anhydrase 9, lyase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 114558.34

Authors

Leitans, J.,Tars, K. (deposition date: 2025-05-27, release date: 2026-05-27)

• Primary citation: Zubriene, A.,Kurtenoka, M.,Paketuryte-Latve, V.,Leitans, J.,Manakova, E.,Zvirblis, M.,Kazaks, A.,Eimonta, V.,Tars, K.,Grazulis, S.,Petrauskas, V.,Matuliene, J.,Dudutiene, V.,Shubin, K.,Matulis, D.; Achieving femtomolar affinities in structure-based drug design.; Eur.Biophys.J., 55:55-62, 2026; PubMed: 41553426; DOI: 10.1007/s00249-025-01812-5

Experimental method

X-RAY DIFFRACTION (2.05 Å)