9R83

KOD-H4 DNA polymerase mutant in a ternary complex with HNA:DNA containing six HNA nucleotides and a 2',3'-dideoxycytidine at the 3'-end of the DNA primer complexed to a natural dATP in the active site

Summary for 9R83

• Entry DOI: 10.2210/pdb9r83/pdb
• Related: 8S84 8S87 9EMI
• Descriptor: DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*CP*AP*C)-3'), DNA polymerase, DNA (5'-D(P*(6HA)P*(6HC)P*(6HT)P*(6HG)P*(6HT)P*GP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), ... (8 entities in total)
• Functional Keywords: polymerase, xna, modified nucleotides, reverse transcriptase, hna, transferase
• Biological source: Thermococcus kodakarensis KOD1; More
• Total number of polymer chains: 6
• Total formula weight: 199039.85

Authors

Gutfreund, C.,Betz, K. (deposition date: 2025-05-15, release date: 2026-07-08)

• Primary citation: Gutfreund, C.,Betz, K.; Crystal structure of a closed ternaryx complex of a HNA Reverse Transcriptase in complex with a HNA/DNA duplex; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)