9R25

Sorafenib in complex with p38alpha (MAPK14)

Summary for 9R25

• Entry DOI: 10.2210/pdb9r25/pdb
• Descriptor: Mitogen-activated protein kinase 14, 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, octyl beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, approved, matched molecular pair, mmp, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 42100.39

Authors

Gomez, S.M.,Buehrmann, M.,Klein, A.,Vasa, S.K.,Weisner, J.,Vatheuer, H.,Czodrowski, P.,Rauh, D.,Linser, R. (deposition date: 2025-04-29, release date: 2026-05-06)

• Primary citation: Gomez, S.M.,Buehrmann, M.,Klein, A.,Vasa, S.K.,Weisner, J.,Vatheuer, H.,Czodrowski, P.,Rauh, D.,Linser, R.; Sorafenib and regorafenib differentially impact the dynamic conformational ensemble of p38alpha; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)