9R0O

Cryo-EM structure of rat SLCO2A1 bound to tolcapone.

Summary for 9R0O

• Entry DOI: 10.2210/pdb9r0o/pdb
• EMDB information: 53486
• Descriptor: Solute carrier organic anion transporter family member 2A1, Tolcapone (2 entities in total)
• Functional Keywords: oatp2a1, plasma membrane localised, prostaglandin transporter, pgt, major facilitator superfamily., membrane protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 72888.36

Authors

Deme, J.C.,Joshi, C.,Lea, S.M.,Newstead, S. (deposition date: 2025-04-24, release date: 2026-02-11)

• Primary citation: Joshi, C.,Deme, J.C.,Nakamura, Y.,Hsu, W.-T.,Goult, J.,Kato, T.,Parker, J.L.,Biggin, P.C.,Lea, S.M.,Nakanishi, T.,Newstead, S.; Structural basis for prostaglandin and drug transport via SLCO2A1.; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.1 Å)