9R0M

Cryo-EM structure of rat SLCO2A1 bound to prostaglandin E2.

Summary for 9R0M

• Entry DOI: 10.2210/pdb9r0m/pdb
• EMDB information: 53484
• Descriptor: Solute carrier organic anion transporter family member 2A1, (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid, CHOLESTEROL HEMISUCCINATE (3 entities in total)
• Functional Keywords: oatp2a1, plasma membrane localized, prostaglandin transporter, pgt, major facilitator superfamily., membrane protein
• Biological source: Rattus norvegicus (Norway rat)
• Total number of polymer chains: 1
• Total formula weight: 73454.31

Authors

Deme, J.C.,Goult, J.,Lea, S.M.,Newstead, S. (deposition date: 2025-04-24, release date: 2026-02-11)

• Primary citation: Joshi, C.,Deme, J.C.,Nakamura, Y.,Hsu, W.-T.,Goult, J.,Kato, T.,Parker, J.L.,Biggin, P.C.,Lea, S.M.,Nakanishi, T.,Newstead, S.; Structural basis for prostaglandin and drug transport via SLCO2A1.; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.2 Å)