9QZI

GID4 in complex with Compound 21

This is a non-PDB format compatible entry.

Summary for 9QZI

• Entry DOI: 10.2210/pdb9qzi/pdb
• Descriptor: Glucose-induced degradation protein 4 homolog, ~{N}-[3-fluoranyl-5-[4-[(3~{S})-3-[2-(2-methoxyethoxy)ethyl]piperidin-1-yl]carbonyl-5-methyl-furan-2-yl]phenyl]-4,4-dimethyl-piperidine-1-carboximidamide (3 entities in total)
• Functional Keywords: ligase, tpd, gid4, compound, complex, targeted protein degradation, ubiquitination
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 20090.41

Authors

Skowron, A.N.,Gorecka-Minakowska, K.M.,Klejnot, M.,Pastok, M.W.,Wisniewski, J.,Walczak, M.J. (deposition date: 2025-04-23, release date: 2026-05-06)

• Primary citation: Skowron, A.N.,Gorecka-Minakowska, K.M.,Klejnot, M.,Pastok, M.W.,Wisniewski, J.,Walczak, M.J.; Novel chemical probes and conformational flexibility of GID4 - a substrate receptor of the Human CTLH E3 ligase complex; To Be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)