9QWK

Crystal structure of S2c-a5b6 TCR in complex with CD1c

Summary for 9QWK

• Entry DOI: 10.2210/pdb9qwk/pdb
• Descriptor: Beta-2-microglobulin,T-cell surface glycoprotein CD1c, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose, ... (12 entities in total)
• Functional Keywords: t cell receptor, tcr, cd1c, lipids, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 603812.21

Authors

Karuppiah, V.,Rangel, V.L. (deposition date: 2025-04-14, release date: 2025-08-20)

Primary citation

Szoke-Kovacs, R.,Khakoo, S.,Rangel, V.L.,Della Cristina, P.,Pentier, J.,Khanolkar, R.,El-Ajouz, S.,Simmons, R.,Cole, D.K.,Gogolak, P.,Salio, M.,Karuppiah, V.
A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c + cells.
Front Immunol, 16:1614610-1614610, 2025

PubMed Abstract: Immunotherapy is emerging as an efficacious treatment for some cancers, complementing traditional chemo-radiation therapies. Specific markers at the cell surface of cancer cells can be used as immunotherapy targets. However, many of these markers are defined by a patient's genetic background, limiting their use across the human population.

PubMed: 40777002
DOI: 10.3389/fimmu.2025.1614610

Experimental method

X-RAY DIFFRACTION (2.27 Å)