9QW8

FKBP12 in complex with bifunctional ligand 1ad and the first bromodomain of BRD4

This is a non-PDB format compatible entry.

Summary for 9QW8

• Entry DOI: 10.2210/pdb9qw8/pdb
• Descriptor: Bromodomain-containing protein 4, Peptidyl-prolyl cis-trans isomerase FKBP1A, ~{N}-[2-[2-[4-[[(1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-2-oxidanylidene-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-5-yl]methoxymethyl]-1,2,3-triazol-1-yl]ethoxy]ethyl]-2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanamide, ... (4 entities in total)
• Functional Keywords: complex, inhibitor, bifunctional, isomerase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 55934.67

Authors

Meyners, C.,Hausch, F. (deposition date: 2025-04-14, release date: 2026-04-29)

• Primary citation: Meyners, C.,Hausch, F.; FKBP12 in complex with bifunctional ligand 1ad and the first bromodomain of BRD4; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)