9QRM

X-ray structure of Kp32gp38 in complex with K21 pyr5

This is a non-PDB format compatible entry.

Summary for 9QRM

• Entry DOI: 10.2210/pdb9qrm/pdb
• Descriptor: Depolymerase 2, capsule K21-specific, (2~{S},4~{a}~{S},6~{R},7~{S},8~{R},8~{a}~{R})-2-methyl-6,7,8-tris(oxidanyl)-4,4~{a},6,7,8,8~{a}-hexahydropyrano[3,2-d][1,3]dioxine-2-carboxylic acid-(4-4)-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-galactopyranose, GLYCEROL, ... (5 entities in total)
• Functional Keywords: klebsiella pneumoniae, phage depolymerase, protein structure, cps degradation, immune response induction, viral protein
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 63943.58

Authors

Napolitano, V.,Squeglia, F.,Privitera, M.,Berisio, R. (deposition date: 2025-04-03, release date: 2025-09-03, Last modification date: 2025-10-01)

Primary citation

Napolitano, V.,Privitera, M.,Drulis-Kawa, Z.,Marasco, D.,Fallarini, S.,Berisio, R.,Squeglia, F.
Structural and functional features of Klebsiella pneumoniae capsular degradation by the phage depolymerase KP32gp38: Implications for vaccination against K. pneumoniae.
Int J Antimicrob Agents, 66:107596-107596, 2025

PubMed Abstract: Klebsiella pneumoniae Przondovirus KP32 presents a complex capsular degradation machinery comprised of two serotype-specific depolymerases, KP32gp38 and KP32gp37.

PubMed: 40846037
DOI: 10.1016/j.ijantimicag.2025.107596

Experimental method

X-RAY DIFFRACTION (1.8 Å)