9QR9

ChiLob 7/4 hIgG1 HC-K219C F(ab')2

Summary for 9QR9

• Entry DOI: 10.2210/pdb9qr9/pdb
• Related: 6FAX
• Descriptor: ChiLob 7/4 hIgG1 heavy chain K219C, ChiLob 7/4 hIgG1 kappa light chain (2 entities in total)
• Functional Keywords: immunostimulatory antibody, tnfr agonist, cancer, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 98685.92

Authors

Elliott, I.G.,Tews, I.,Orr, C.M. (deposition date: 2025-04-03, release date: 2026-10-14, Last modification date: 2026-10-21)

• Primary citation: Elliott, I.G.,Tews, I.,Orr, C.M.,Fisher, H.R.,Essex, J.W.,Cragg, M.S.; Disulfide engineering as an approach to reduce conformational flexibility of immunostimulatory antibodies to enhance receptor agonism; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.491 Å)