9QQS

Structure of the MEGF8-MOSMO complex with nanobody 270 (Focused refinement)

This is a non-PDB format compatible entry.

Summary for 9QQS

• Entry DOI: 10.2210/pdb9qqs/pdb
• Related: 9QRU 9QS3 9QS6 9QSH 9QTY
• EMDB information: 53313
• Descriptor: Modulator of smoothened protein, Isoform 2 of Multiple epidermal growth factor-like domains protein 8, Nanobody 270, ... (6 entities in total)
• Functional Keywords: e3 ubiquitin ligase, hedgehog signaling, single-pass membrane protein, membrane protein complex, smoothened, tetraspanin, cell surface receptor, primary cilium, morphogen, signal transduction, human, carpenter syndrome, cancer, nanobody, palmitoylation, gdn, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 88011.22

Authors

Williams, C.,Carrique, L.,Pardon, E.,Nocka, L.M.,Hedger, G.,Pusapati, G.V.,Parashara, P.,Latorraca, N.R.,Sarkar, P.,Lartey, D.,Gao, L.,Milenkovic, L.,Chalk, R.,Steyaert, J.,Bazan, F.,Rouse, S.L.,Marqusee, S.,Kong, J.H.,Rohatgi, R.,Siebold, C. (deposition date: 2025-04-02, release date: 2026-05-27)

• Primary citation: Williams, C.,Nocka, L.M.,Hedger, G.,Carrique, L.,Pusapati, G.V.,Parashara, P.,Latorraca, N.,Sarkar, P.,Lartey, D.,Gao, L.,Pardon, E.,Milenkovic, L.,Steyaert, J.,Chalk, R.,Bazan, F.,Rouse, S.L.,Marqusee, S.,Kong, J.H.,Siebold, C.,Rohatgi, R.; Design principles of a membrane-spanning ubiquitin ligase; Mol Cell, 2026; DOI: 10.1016/j.molcel.2026.05.001

Experimental method

ELECTRON MICROSCOPY (2.65 Å)