9QHA

Crystal structure of human dendritic cell immunoreceptor (DCIR) extracellular domain in complex with galactose-terminated biantennary complex-type N-glycan

Summary for 9QHA

• Entry DOI: 10.2210/pdb9qha/pdb
• Descriptor: C-type lectin domain family 4 member A, alpha-D-galactopyranose-(1-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-galactopyranose-(1-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: c-type lectin, dcir, extracellular domain, glycan, sugar binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 41687.41

Authors

Demange, P.,Rombouts, Y.,Rousset, S.,Tranier, S. (deposition date: 2025-03-14, release date: 2026-09-30)

• Primary citation: Raymond, B.B.A.,Sneperger, T.,Rousset, S.,Gilles, N.,Bally, A.,Stella, A.,Hipgrave Ederveen, A.L.,Marcoux, J.,Trimaglio, G.,Thepaut, T.,Lagarrigue, F.,Burlet-Schiltz, O.,Wuhrer, M.,Fieschi, F.,Demange, P.,Neyrolles, O.,Rombouts, Y.; The human and mouse dendritic cell receptor DCIR binds to LRP1 N-glycans containing terminal galactoses, including the alpha-Gal antigen; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)