9QFN

Crystal structure of T2R-TTL-Li5 complex

Summary for 9QFN

Entry DOI	10.2210/pdb9qfn/pdb
Descriptor	Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (15 entities in total)
Functional Keywords	tubulin, microtubulues, colchicine, li5, cell cycle
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	6
Total formula weight	270613.30
Authors	Oliva, M.A.,Balaguer, F.A.,Diaz, J.F. (deposition date: 2025-03-12, release date: 2026-03-25)
Primary citation	DiSiervi, N.,Balaguer, F.A.,Yong, A.,Revuelta, V.,Oliva, M.A.,Cardenas, M.,Calvo-Vidal, M.N.,Barasoain, I.,Krumsiek, J.,Glickman, J.F.,Melnick, A.,Diaz, J.F.,Pera, B.,Zamponi, N.,Cerchietti, L. Phenotypic-screening identifies a new class of cytoskeleton inhibitor with activity in diffuse large B cell lymphoma with functional BCR To Be Published,
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation