9QB9

CK2, catalytic subunit alpha' (CSNK2A2 gene product) in complex with a heparin-derived trisaccharide and the ATP-competitive inhibitor 4w

This is a non-PDB format compatible entry.

Summary for 9QB9

• Entry DOI: 10.2210/pdb9qb9/pdb
• Descriptor: Casein kinase II subunit alpha', 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 1,3-bis(bromanyl)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, ... (5 entities in total)
• Functional Keywords: ck2, fragment-based screening, protein kinase, protein kinase ck2, casein kinase ii, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 44821.88

Authors

Werner, C.,Harasimowicz, H.,Weiss, M.S.,Niefind, K. (deposition date: 2025-03-01, release date: 2026-01-21)

• Primary citation: Werner, C.,Barthel, T.,Harasimowicz, H.,Marminon, C.,Weiss, M.S.,Borgne, M.L.,Niefind, K.; Crystallographic Fragment Screening with CK2 alpha’, an Isoform of Human Protein Kinase CK2 Catalytic Subunit, and Its Use to Obtain a CK2 alpha’/Heparin Complex Structure; Kinases Phosphatases, 4:1-, 2026; DOI: 10.3390/kinasesphosphatases4010001

Experimental method

X-RAY DIFFRACTION (1.19 Å)