9QB6

Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment H02 and CX-4945 (Silmitasertib)

Summary for 9QB6

• Entry DOI: 10.2210/pdb9qb6/pdb
• Descriptor: Casein kinase II subunit alpha', 3-cyclopentyl-1-(piperazin-1-yl)propan-1-one, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, ... (4 entities in total)
• Functional Keywords: ck2, fragment-based screening, protein kinase, protein kinase ck2, casein kinase ii, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43992.62

Authors

Werner, C.,Harasimowicz, H.,Barthel, T.,Weiss, M.S.,Niefind, K. (deposition date: 2025-02-28, release date: 2026-01-14)

• Primary citation: Werner, C.,Barthel, T.,Harasimowicz, H.,Marminon, C.,Weiss, M.S.,Borgne, M.L.,Niefind, K.; Crystallographic Fragment Screening with CK2 alpha', an Isoform of Human Protein Kinase CK2 Catalytic Subunit, and Its Use to Obtain a CK2 alpha'/Heparin Complex Structure; Kinases Phosphatases, 4:1-, 2026; DOI: 10.3390/kinasesphosphatases4010001

Experimental method

X-RAY DIFFRACTION (1.05 Å)