9QB4

Yeast 20S proteasome mutant: beta5_T3M in complex with Carfilzomib

This is a non-PDB format compatible entry.

Summary for 9QB4

• Entry DOI: 10.2210/pdb9qb4/pdb
• Related: 5CZ4
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-5, ... (19 entities in total)
• Functional Keywords: proteasome, proteasome associated autoinflammatory syndromes, mutation, assembly, maturation, hydrolase
• Biological source: Saccharomyces cerevisiae (brewer's yeast); More
• Total number of polymer chains: 34
• Total formula weight: 736833.61

Authors

Huber, E.M.,Heinemeyer, W.,Groll, M. (deposition date: 2025-02-28, release date: 2025-04-02, Last modification date: 2025-04-09)

• Primary citation: Huber, E.M.,Heinemeyer, W.,Groll, M.; Proteasome-associated autoinflammatory syndromes: the impact of mutations in proteasome subunits on particle assembly, structure and activity; to be published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)