9Q9T

Human ROCK2 in complex with a dihydropyrazolo-pyrimidine inhibitor

This is a non-PDB format compatible entry.

Summary for 9Q9T

• Entry DOI: 10.2210/pdb9q9t/pdb
• Related: 9Q8R
• Descriptor: Rho-associated protein kinase 2, (7~{S})-7-(2,3-dihydro-1~{H}-inden-2-yl)-2-(hydroxymethyl)-~{N}-isoquinolin-6-yl-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide (3 entities in total)
• Functional Keywords: rho-associated protein kinase 2, kinase inhibitor, dihydropyrazolo-pyrimidine scaffold, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 185406.58

Authors

Pala, D.,Clark, D.,Accetta, A.,Rancati, F.,Edwards, C. (deposition date: 2025-02-26, release date: 2026-06-10)

• Primary citation: Edwards, C.,Cantoni, S.,Pala, D.,Pasqua, E.,Pastore, F.,Rancati, F.,Clark, D.,Bhalay, G.,Vaccaro, F.,Riccardi, B.,Fioni, A.,Bassanetti, I.,Pioselli, B.,Patacchini, R.,Facchinetti, F.,Accetta, A.; Discovery of a Selective Inhaled Rho Kinase Inhibitor with Therapeutic Effects in Experimental Pulmonary Hypertension; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.96 Å)