9Q9A

Protein kinase CK2 catalytic subunit alpha' (CSNK2A2 gene product) in complex with F2X-Entry screen fragment C06 and CX-4945 (Silmitasertib)

This is a non-PDB format compatible entry.

Summary for 9Q9A

• Entry DOI: 10.2210/pdb9q9a/pdb
• Descriptor: Casein kinase II subunit alpha', 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, ~{N}-(3-chloranyl-4-methyl-phenyl)ethanamide, ... (5 entities in total)
• Functional Keywords: fragment-based screening, protein kinase ck2, casein kinase ii, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 44001.39

Authors

Werner, C.,Harasimowicz, H.,Barthel, T.,Weiss, M.S.,Niefind, K. (deposition date: 2025-02-26, release date: 2026-01-14)

• Primary citation: Werner, C.,Barthel, T.,Harasimowicz, H.,Marminon, C.,Weiss, M.S.,Borgne, M.L.,Niefind, K.; Crystallographic Fragment Screening with CK2 alpha', an Isoform of Human Protein Kinase CK2 Catalytic Subunit, and Its Use to Obtain a CK2 alpha'/Heparin Complex Structure; Kinases Phosphatases, 4:1-, 2026; DOI: 10.3390/kinasesphosphatases4010001

Experimental method

X-RAY DIFFRACTION (1.03 Å)