9Q5A

Cryo-EM structure of a Paracoccus Trimethylamine N-oxide Demethylase mutant (D220A/D367A)in Complex with TMAO

Summary for 9Q5A

• Entry DOI: 10.2210/pdb9q5a/pdb
• Related: 1WOO 9Q59
• EMDB information: 72224
• Descriptor: Trimethylamine N-oxide Demethylase, ZINC ION, trimethylamine oxide (3 entities in total)
• Functional Keywords: trimethylamine n-oxide demethylase, paracoccus, substrate channeling, cryo-em, metal binding protein
• Biological source: Paracoccus sp. DMF
• Total number of polymer chains: 4
• Total formula weight: 347941.41

Authors

Thach, T.,Subramanian, R. (deposition date: 2025-08-20, release date: 2026-08-26)

• Primary citation: Thach, T.,Dhanabalan, K.,Maurya, S.,Han-Hallet, Y.,Quan, S.,Allison, J.,Ramanathan, G.,Subramanian, R.; Bifunctional Architecture Enables Substrate Catalysis and Channeling in Paracoccus TMAO Demethylase; Elife, 2026; DOI: 10.7554/elife.109964.2

Experimental method

ELECTRON MICROSCOPY (2.8 Å)