9Q54

Structure of human endothelial nitric oxide synthase heme domain bound with 6-((2,3-difluoro-5-(2-(3-fluoroazetidin-1-yl)ethyl)phenoxy)methyl)-4-methylpyridin-2-amine

This is a non-PDB format compatible entry.

Summary for 9Q54

• Entry DOI: 10.2210/pdb9q54/pdb
• Descriptor: Nitric oxide synthase 3, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... (11 entities in total)
• Functional Keywords: nitric oxide synthase inhibitor binding, oxidoreductase-inhibitor complex, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 205295.58

Authors

Li, H.,Poulos, T.L. (deposition date: 2025-08-20, release date: 2025-09-10)

• Primary citation: Ansari, A.,Rathnayake, A.D.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B.; Design and synthesis of 7-aryl-6-fluoro-2-aminoquinolines as potent and highly selective human neuronal nitric oxide synthase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.13 Å)