9Q4K

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain bound with 6-((2,3-difluoro-5-(2-(piperidin-1-yl)ethyl)phenoxy)methyl)-4-methylpyridin-2-amine

This is a non-PDB format compatible entry.

Summary for 9Q4K

• Entry DOI: 10.2210/pdb9q4k/pdb
• Descriptor: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 6-({2,3-difluoro-5-[2-(piperidin-1-yl)ethyl]phenoxy}methyl)-4-methylpyridin-2-amine, ... (7 entities in total)
• Functional Keywords: nitric oxide synthase inhibitor binding, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 201547.16

Authors

Li, H.,Poulos, T.L. (deposition date: 2025-08-20, release date: 2025-09-10)

• Primary citation: Ansari, A.,Chrzanowski, R.T.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B.; Highly potent, selective, and membrane permeable ether linked 2-aminopyridine-based human neuronal nitric oxide synthase inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.198 Å)