9Q3S

Cryo-EM structure of PGT121 Fab and Rhesus macaque Ab4 Fab in complex with HIV-1 Env trimer BG505 SOSIP.664

Summary for 9Q3S

• Entry DOI: 10.2210/pdb9q3s/pdb
• EMDB information: 72206
• Descriptor: BG505 SOSIP.664 gp41, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (12 entities in total)
• Functional Keywords: hiv-1 env, broadly-neutralizing antibodies (bnabs), glycan hole, cd4-binding site (cd4bs), viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 18
• Total formula weight: 528341.55

Authors

Chandravanshi, M.,Tolbert, W.D.,Pazgier, M. (deposition date: 2025-08-19, release date: 2026-05-27)

• Primary citation: Chandravanshi, M.,Tolbert, W.D.,Pazgier, M.; Cryo-EM structure of PGT121 Fab and Rhesus macaque Ab4 Fab in complex with HIV-1 Env trimer BG505 SOSIP.664; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.01 Å)