9Q12

Human telomerase catalytic core with shelterin protein TPP1 and DNA primer ending in TTAG

Summary for 9Q12

• Entry DOI: 10.2210/pdb9q12/pdb
• EMDB information: 72114
• Descriptor: Telomerase RNA, Telomerase reverse transcriptase, Telomeric repeat substrate, ... (6 entities in total)
• Functional Keywords: dna polymerase, reverse transcriptase, ribonucleoprotein, rna binding protein, rna binding protein-rna-dna complex, rna binding protein/rna/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 328780.06

Authors

Wang, Y.,Liu, B.,He, Y.,Feigon, J. (deposition date: 2025-08-13, release date: 2026-06-17)

• Primary citation: Wang, Y.,Liu, B.,He, Y.,Feigon, J.; Structures of telomerase with BIBR1532 reveal novel mechanism of inhibition; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.8 Å)