9PV0

NorA in outward-open conformation bound to inhibitor IMP2380

This is a non-PDB format compatible entry.

Summary for 9PV0

• Entry DOI: 10.2210/pdb9pv0/pdb
• EMDB information: 71880
• Descriptor: Quinolone resistance protein NorA, Soluble cytochrome b562 chimera, (3E)-3-(1,3-benzothiazol-2-yl)-4-[3-(4-chlorophenyl)-1-methyl-1H-pyrazol-4-yl]but-3-enoic acid (2 entities in total)
• Functional Keywords: efflux pump, membrane protein, transport protein-inhibitor complex, transport protein/inhibitor
• Biological source: Staphylococcus aureus; More
• Total number of polymer chains: 1
• Total formula weight: 54593.25

Authors

Suwatthee, T.,Gray, J.L.,Ledger, E.V.K.,Wang, D.,Edwards, A.,Tate, E.W.,Traaseth, N.J. (deposition date: 2025-07-31, release date: 2026-08-05)

• Primary citation: Gray, J.L.,Ledger, E.V.K.,Suwatthee, T.,Lanyon-Hogg, T.,Burden, T.J.,Arvaniti, K.,Sefton, A.,Papagora, L.E.,Clarke, T.B.,Riley, J.,Pinto, E.G.,Cunningham, F.,Gilbert, I.H.,Gray, D.,Wang, D.,Read, K.D.,Traaseth, N.J.,Edwards, A.,Tate, E.W.; Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.52 Å)