9PKI

Phenylalanine ammonia-lyase from Joinvillea ascendens in complex with tyrosine

Summary for 9PKI

• Entry DOI: 10.2210/pdb9pki/pdb
• Descriptor: Phenylalanine ammonia-lyase from Joinvillea ascendens in complex with tyrosine, TYROSINE (3 entities in total)
• Functional Keywords: enzyme phenylalanine ammonia-lyase phenylpropanoid biosynthesis, lyase
• Biological source: Joinvillea ascendens
• Total number of polymer chains: 1
• Total formula weight: 77695.74

Authors

Morris, J.S.,Jez, J.M. (deposition date: 2025-07-14, release date: 2026-08-19, Last modification date: 2026-09-02)

Primary citation

Takeda-Kimura, Y.,Moore, B.,Holden, S.,Morris, J.S.,Deb, S.K.,Sanders, C.,El-Azaz, J.,Barrett, M.,Lorence, D.,de Oliveira, M.V.V.,Havranek, W.,Grimwood, J.,Williams, M.,Boston, L.B.,Jenkins, J.,Plott, C.,Shu, S.,Barry, K.,Goodstein, D.M.,Schmutz, J.,Jez, J.M.,Moscou, M.J.,McKain, M.R.,Leebens-Mack, J.H.,Maeda, H.A.
Genomes of Poaceae relatives reveal key metabolic innovations preceding the evolution of grasses.
Science, 393:eadv0443-eadv0443, 2026

PubMed Abstract: The grass family (Poaceae) has immense economic and ecological importance and exhibits distinctive metabolic traits, including dual starch and lignin biosynthetic pathways. We sequenced the genomes of , , , and species to investigate when and how these metabolic innovations evolved relative to the origin of the grass family. The whole-genome duplication (ρWGD) within the lineage that led to the last common ancestor of all grasses contributed to the gene family expansions underlying cytosolic starch biosynthesis, whereas an earlier tandem duplication of () gave rise to (), which is responsible for the dual lignin biosynthesis. Integrated biochemical, functional, and structural studies, guided by phylogenomic analyses, further revealed the molecular basis of key metabolic innovations predating the evolution of grasses.

PubMed: 42623474
DOI: 10.1126/science.adv0443

Experimental method

X-RAY DIFFRACTION (2.75 Å)