9PHG

Ketoreductase Engineering for a Chemoenzymatic Fluorination and Dynamic Kinetic Reduction Cascade

Summary for 9PHG

• Entry DOI: 10.2210/pdb9phg/pdb
• Descriptor: ketoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: rossmann fold, ketoreductase, oxidoreductase
• Biological source: Sporobolomyces salmonicolor
• Total number of polymer chains: 2
• Total formula weight: 79141.59

Authors

Hruza, A.,Chun, S. (deposition date: 2025-07-09, release date: 2025-07-30)

• Primary citation: Chun, S.W.,Kosjek, B.,Cahn, J.K.B.,Makarewicz, A.M.,Cheung-Lee, W.L.,Verma, D.,Jones, C.M.,Hruza, A.,Forstater, J.H.,Li, S.,Gallagher, Q.,Murphy, G.S.,Moore, J.C.; Ketoreductase Engineering for a Chemoenzymatic Fluorination and Dynamic Kinetic Reduction Cascade; Acs Catalysis, :13059-13068, 2025; DOI: 10.1021/acscatal.5c01769

Experimental method

X-RAY DIFFRACTION (1.479 Å)