9PAM

Crystal structure of HCoV-OC43 3CLpro with ALG-097655 (Inhibitor 2)

This is a non-PDB format compatible entry.

Summary for 9PAM

• Entry DOI: 10.2210/pdb9pam/pdb
• Descriptor: 3C-like proteinase, (1R,2S,3S,6R,7S)-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-4-[(2S)-4,4,4-trifluoro-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl]-4-azatricyclo[5.2.1.0~2,6~]dec-8-ene-3-carboxamide (non-preferred name) (3 entities in total)
• Functional Keywords: hydrolase/inhibitor, hcov-oc43, 3cl pro, mpro, nsp5, alg-097655, inhibitor 2, pan coronavirus durg, viral protein
• Biological source: Human coronavirus OC43
• Total number of polymer chains: 2
• Total formula weight: 67939.56

Authors

Reddem, E.R.,Forouhad, F.,Shapiro, L.,Stoycheva, A. (deposition date: 2025-06-25, release date: 2026-07-01)

• Primary citation: Reddem, E.R.,Forouhad, F.,Shapiro, L.,Stoycheva, A.; Crystal structure of HCoV-OC43 3CLpro with ALG-097655 (Inhibitor 2); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.31 Å)